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  • Gene Machine: The Race to Decipher the Secrets of the Ribosome
  • Venki Ramakrishnan
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  • 12 March 2019
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Venki Ramakrishnan Á 5 Free read

Gene Machine: The Race to Decipher the Secrets of the Ribosome Read & Download ¼ 5 Venki Ramakrishnan Á 5 Free read To the development of better antibiotics against life threatening diseases But this is also a human story of Ramakrishnans unlikely journey from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the worlds best scientists In the end Gene Machine is a frank insiders account of the pursuit of high stakes scienc. I saw the author commenting on the nature of BBC News on the telly His English accent was SurreySussex Home Counties despite being born in India and spending most of his adult life in the United StatesThe book gives the reader some idea of the slog which is the daily life of a professional scientist It also illuminates the conflicts of interests involved in the collabratistcompetitive nature of potential Nobel Prize winners Professional Science involves teamwork and yet only the team leader gets the prizeI found the paperback version print a little small and hard on the eyes Perhaps in the second edition the author will address this My own book Helpless as a Baby might serve as an example Les relations internationales depuis 1945 yet only the team leader gets the prizeI found the paperback version print a little small and hard on the eyes Perhaps in the second edition the author will address this My own book Helpless as a Baby might serve as an example

review Gene Machine: The Race to Decipher the Secrets of the Ribosome

Gene Machine: The Race to Decipher the Secrets of the Ribosome

Gene Machine: The Race to Decipher the Secrets of the Ribosome Read & Download ¼ 5 Venki Ramakrishnan Á 5 Free read DNA is just an inert blueprint for life It is the ribosome an enormous molecular machine made up of a million atoms that makes DNA come to life turning our genetic code into proteins and therefore into us Gene Machine is an insider account of the race for the structure of the ribosome a fundamental discovery that both advances our knowledge of all life and could lead. DNA has lodged itself in the public imagination as the blueprint of life and as other often slightly deceiving metaphors But what happens next How do organisms actually get anything done with the information coded in DNA For biologists this is standard textbook fare DNA is copied into single stranded RNA which is then translated three letters at a time into amino acids that when strung together make up the workhorses of the cell proteins The cell organ or organelle that does the latter part is the ribosome which Venki Ramakrishnan introduces here in Gene Machine He has written a riveting first hand account of the academic race to describe its structure and how in the process he bagged a shared Nobel Prize in Chemistry in 2009Ramakrishnan initially intended to become a theoretical physicist but soon became fascinated with biology After finishing his PhD in physics he started over as a biology graduate The bulk of this book describes how he became enamoured with learning about the ribosome and spent decades studying it going from student to postdoc to professorship all the while recruiting brilliant students and colleagues to collaborate with But he did not operate alone As the decades progressed and of the ribosome s structure was clarified competition for publication in top tier journals intensified Various research groups around the world were working in parallel towards the same goal a complete detailed structural description of all the protein and RNA elements making up a ribosomeRamakrishnan has purposefully decided to make this book foremost a personal memoir of his contributions during those decades of research and of those of his collaborators and competitors He describes the many pitfalls mistakes tensions and rivalries with disarming honesty and gives a very good picture of what real science looks like in the wild If you were hoping for an accessible overview of the current state of ribosome biology this book might leave you wanting For example Ramakrishnan almost off handedly mentions how we have come to learn that the ribosome doesn t exist but there seem to be many types something which he does not elaborate on Another interesting observation is that the core of ribosomes consists entirely of RNA with various clusters of proteins on the outside Since many scientists think that life started off as single stranded RNA acuiring the ability to self replicate see Life from an RNA World The Ancestor within this could point to how the ribosome evolved By the time the structure of the ribosome was finally elucidated by x ray crystallography further technical developments in electron microscopy made it possible to use that techniue instead with superior results This is very reminiscent of the rapid developments in DNA seuencing where the first efforts were herculean and incredibly costly after which new developments accelerated and eased the process tremendouslyI would have loved to know about these and other details especially as there is no good popular science book on ribosomes so far instead DNA gets all the love see for example The Gene An Intimate History She Has Her Mother s Laugh The Powers Perversions and Potential of Heredity or Blueprint How DNA Makes Us Who We Are I am convinced that Ramakrishnan could have written a fantastically readable overview as he does a good job of familiarising readers with his method of choice x ray crystallography and with the function and structure of the ribosome making good use of illustrationsAs a science memoir however the book is a great read that I could barely put down and gives an honest insider s account of the competitive nature of scientific research L'Atlas des stars d'Hollywood : Les acteurs de l'âge d'or you were hoping for an accessible overview of the current state of ribosome biology this book might leave Géopolitique de l'Arabie Saoudite : La guerre intérieure you wanting For example Ramakrishnan almost off handedly mentions how we have come to learn that the ribosome doesn t exist but there seem to be many types something which he does not elaborate on Another interesting observation is that the core of ribosomes consists entirely of RNA with various clusters of proteins on the outside Since many scientists think that life started off as single stranded RNA acuiring the ability to self replicate see Life from an RNA World The Ancestor within this could point to how the ribosome evolved By the time the structure of the ribosome was finally elucidated by x ray crystallography further technical developments in electron microscopy made it possible to use that techniue instead with superior results This is very reminiscent of the rapid developments in DNA seuencing where the first efforts were herculean and incredibly costly after which new developments accelerated and eased the process tremendouslyI would have loved to know about these and other details especially as there is no good popular science book on ribosomes so far instead DNA gets all the love see for example The Gene An Intimate History She Has Her Mother s Laugh The Powers Perversions and Potential of Heredity or Blueprint How DNA Makes Us Who We Are I am convinced that Ramakrishnan could have written a fantastically readable overview as he does a good job of familiarising readers with his method of choice x ray crystallography and with the function and structure of the ribosome making good use of illustrationsAs a science memoir however the book is a great read that I could barely put down and gives an honest insider s account of the competitive nature of scientific research

Download ☆ PDF, eBook or Kindle ePUB free Á Venki Ramakrishnan

Gene Machine: The Race to Decipher the Secrets of the Ribosome Read & Download ¼ 5 Venki Ramakrishnan Á 5 Free read A Nobel Prize winning biologist tells the riveting story of his race to discover the inner workings of biologys most important molecule Ramakrishnans writing is so honest lucid and engaging that I could not put this book down until I had read to the very end Siddhartha Mukherjee author of The Emperor of All Maladies and The Gene Everyone has heard of DNA But by itself. Dr Ramakrishnan documents his and countless other scientists role in the tour de force that was the determination of the structure of the ribosome Easily one of the greatest stories in academic science on par with the discovery of the double helical structure of DNA and a must read for any young aspiring structural biologist